Karan Kumar
Research Scholar, Jaipur College of Pharmacy, Jaipur, Rajasthan, India
Mayank Bansal
Professor and Principal, Jaipur College of Pharmacy, Jaipur, Rajasthan, India
Rakesh Gupta
Professor, Jaipur College of Pharmacy, Jaipur, Rajasthan, India
Abstract
In pharmaceutical research, a new age of science and technology focuses on oral medication delivery. Tablets and capsules have limited bioavailability, frequent use, adverse effects, and patient noncompliance. By creating unique medication delivery mechanisms, researchers avoided established systems. In paediatrics and geriatrics, fast-dissolving medication delivery devices are popular. Orally disintegrating films are better than fast-dissolving pills, which might suffocate. Because they circumvent disintegration and the first pass impact following oral administration, they're popular.
The oral fast-dissolving film is a revolutionary, enhanced delivery technology. This dosage form is gaining popularity because to its cost-benefit, quick dissolving without water, and compliance with elderly and pediatric patients in emergency situations and certain disorders. Also, it's a good dose form for drugs with pre-systemic metabolism and low bioavailability. Recently, quick dissolving films have become a popular alternative to tablets. The films disintegrate over a moist surface, such as the tongue, within seconds, so the user may ingest the medication without extra liquid. Convenience boosts marketing and patient compliance. As the medicine is immediately taken into systemic circulation, degradation and first pass effect are avoided. These factors make this formulation popular and acceptable among pediatric, geriatric, and choking patients. Over-the-counter pain and motion sickness films are sold in the US. Thin film formats are developed using transdermal medication delivery technology. This review article discusses the history, benefits, drawbacks, limits, ideal qualities, classification, formulation, method of manufacture, in-vitro and in-vivo quality metrics, technological advancements, commercial trends, and past work on oral rapid dissolving films. It's one of the fastest-growing dosage forms due to its unique properties, innovative attributes, competitive position, and cost-adequacy.
Keywords: Fast dissolving film, oral formulation, novel, first pass metabolism, patient compliance