http://www.ijpba.in/index.php/ijpba/issue/feedInternational Journal of Pharmaceutical and Biological Science Archive2024-02-24T13:24:46+00:00A Guptaeditor@ijpba.inOpen Journal Systems<p> </p> <hr> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><span style="color: blue; text-align: justify;"><span style="color: #000000;"><span style="box-sizing: inherit;"><strong style="box-sizing: inherit;"><span style="box-sizing: inherit;">International Journal of Pharmaceutical and Biological Science Archive (IJPBA)</span></strong></span><strong style="color: #009999; font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11.2px;"> </strong></span></span><span style="color: #000000;"><span style="text-align: justify;"><strong style="box-sizing: inherit;"><span style="box-sizing: inherit;">(</span></strong></span><span style="text-align: justify;">ISSN 2349-2678) </span></span><span style="text-align: justify;">is a peer-reviewed bi-monthly journal dedicated to the publication of research papers, reviews, mini-reviews, Short</span><span style="text-align: justify; z-index: 2147483647;"> communications </span><span style="text-align: justify;">and case studies. This publication is aimed at a broad, interdisciplinary audience of academic and industrial researchers actively engaged in basic and applied laboratory practice, related to Pharmaceutical Science and Therapeutics.</span></span></span></p> <hr> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Physiotherapeutic Rehabilitation and Medical Science || Dentistry || Ayurveda || Homeopathy || </strong></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Anatomy, Physiology, Biochemistry, Molecular Biology, Cell biology, Genetics, Hematology, Pathology, Immunology, Microbiology, Virology, Parasitology, Surgery, Dental Sciences, Sports Physiology, Histopathology, Toxicology and all major disciplines of Biomedical Sciences.</span></span></p> <hr> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Pharmaceutical Sciences || Allied Sciences </strong></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Pharmacology and Toxicology, Pharmaceutical and Biomedical Analysis, Clinical Research, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology and all major disciplines of Pharmaceutical Sciences.</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Articles are published as they are accepted and are freely available on the journal’s website to facilitate rapid and broad dissemination of research findings to a global audience.</span></span></p> <hr> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Top Reasons for publication with us</strong></span></span></p> <hr> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Quick Quality Review:</strong> The journal has strong international team of editors and reviewers, Rapid Decision and Publication</span></span></p> <hr> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Very Low Publication Fees:</strong> Comparable journals charge a huge sum for each accepted manuscript. JPBR only charge the fees necessary to recoup cost associated with running the journal</span></span></p> <hr> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Other features:</strong> DIDS Assigned and Implemented the Open Review System (ORS).</span></span></p> <hr> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Important Notice:</strong></span></span></p> <hr> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Author can now directly send their manuscript as an email attachment to <strong style="font-size: 14px; font-family: 'lucida sans unicode', 'lucida grande', sans-serif;">|| <span style="color: #0000ff;">editor@ijpba.in</span> || <span style="color: #0000ff;">editorijpba.in@gmail.com</span> || Call: <span style="color: #008000;">+91-9680566708 </span>||</strong></span></span></p> <hr> <p> </p>http://www.ijpba.in/index.php/ijpba/article/view/449Adaptogenic Potential of Pithecellobium Dulce Leaf Extract: An Experimental Study2024-01-05T05:49:36+00:00Md Abdul Qayyum F Jahagirdareditor@ijpba.inRakesh Kumar Jateditor@ijpba.in<h1><em>Pithecellobium dulce leaf</em> (Fabaceae) is a medicinal plant used in the treatment of many clinical conditions in India. Its adaptogenic potential activity has been investigated in this study using albino mice and rats. The methanolic extract of <em>Pithecellobium dulce leaves</em> was prepared and subjected to preliminary qualitative phytochemical screening. Flavanoids, Tannins and Alkaloids were found to be present. Acute toxicity studies were carried out in albino mice. The methanolic extract did not show the lethal effect at a dose of 2000mg/kg body weight with no signs of abnormalities or any mortality observed for 14 days period. Anoxia stress tolerance test, Swimming endurance test, Immobilisation stress models were used to investigate the adaptogenic potential of title plant. The results indicate that pretreatment with methanolic extract of leaves of <em>Pithecellobium dulce </em>exhibited significant adaptogenic potential activity at the tested doses of 125mg/ kg and 250 mg/ kg 500 mg/kg. On the basis of results, it was concluded that <em>Pithecellobium dulce leaves</em> possess adaptogenic potential activity.</h1> <p><strong>Keywords: </strong><em>Pithecellobium dulce</em><em> leaf</em>, anoxia stress tolerance test, swimming endurance test model, Immobilization stress.</p>2024-01-05T00:00:00+00:00##submission.copyrightStatement##http://www.ijpba.in/index.php/ijpba/article/view/450Toxicity Study and Anti-Diabetic Activity of Indeginious Traditional Medicinal Plant Syzygium Cumini2024-01-05T05:53:01+00:00Shekhar Shivaji GaikwadEDITOR@IJPBA.INRenu SinghEDITOR@IJPBA.INRakesh JatEDITOR@IJPBA.IN<p style="font-weight: 400;"><em>Syzygium cumini is used as traditional medicines to treat diabetes mellitus</em>. <em> The current study is done on treatment of diabetes mellitus with various herbal plants of Maharashtra region. Initially acute toxicity studies were performed, and diabetes is induced in rats with alloxane and streptozocin in laboratory. Alloxan induced diabetes is like type I diabetes due to deficiency of insulin in the body because of no release of insulin and type II diabetes is studied on the basis of hyperglycemia or obesity of the patients. These are treated with different plant extracts and comparison is done with standard antidiabetic drug.</em></p> <p style="font-weight: 400;"><em>The most important plant syzygium cumini is selected from Maharshtra vidharbha region and this is also found all over the country and most widely utilized for controlling sugar and lipid profile. Here these plants and their toxicity were studies for antidiabetic purpose. Jamun plant fruits and seeds are useful constituents for extraction and isolation of active constituents.</em></p> <p><strong>Keywords</strong>: diabetes, syzygium cumini, extraction and evaluation, toxicity, anti-diabetes evaluation.</p>2024-01-05T00:00:00+00:00##submission.copyrightStatement##http://www.ijpba.in/index.php/ijpba/article/view/451CYBER SECURITY CHALLENGES WITHIN THE CONNECTED HOME ECOSYSTEM FUTURES2024-01-10T16:07:03+00:00P. Vivekanandeditor@ijpba.inKusum Rajawateditor@ijpba.in<p style="font-weight: 400;">The future of linked home ecosystems is far closer to cybercrime and cyber security risks than was previously believed. Most studies examine the protection mechanisms of government and corporate networks, but the gadgets utilized in today's and tomorrow's linked smart homes provide a significant vulnerability. This report is a component of a larger study looking at the effects and obstacles posed by cybersecurity threats to internet-connected smart gadgets in the home. We discuss the history and drivers behind the increasing need for all of our smart gadgets to work together seamlessly, so that we can provide our consumers access to a wide range of features and capabilities. Despite these technologies' increased utility, the report stresses the fact that they also pose new dangers. Then, we go into the current cybersecurity concerns surrounding smart devices in smart homes and examine them in depth.</p> <p><strong>Keywords: </strong>cyber security, cybercrime, cyber physical systems, connected home, mobile malware.</p>2024-01-05T00:00:00+00:00##submission.copyrightStatement##http://www.ijpba.in/index.php/ijpba/article/view/452MANAGEMENT AND CONSERVATION OF AQUATIC BIODIVERSITY2024-01-10T16:21:55+00:00B. Deepakeditor@ijpba.inShivarti Gautameditor@ijpba.in<p style="font-weight: 400;">The inland fisheries industry is crucial to the country's socioeconomic growth, and the inland water resources are home to a wealth of aquatic species. India is the world's second-largest fish producer, and the country's fishing industry has seen a dramatic paradigm change from one dominated by the sea to one centered on the country's vast interior waterways. Pollution, water abstraction, flow alteration, eutrophication, the spread of invasive alien species, climate change, urbanization, etc. are all contributing to the degradation of inland aquatic resources. The loss of aquatic biodiversity poses a serious threat to India's food, nutritional, and economic security, and must be addressed immediately. The current research has led to suggestions for protecting India's aquatic resources, particularly those of high biodiversity and ecological value.</p> <p><strong>Key words:</strong> Aquaculture, Aquatic, Biodiversity, Fisheries, Conservation.</p>2024-01-05T00:00:00+00:00##submission.copyrightStatement##http://www.ijpba.in/index.php/ijpba/article/view/453MARKETING STRATEGIES FOR E-COMMERCE THAT INFLUENCE CUSTOMERS' PURCHASES AT ONLINE STORES2024-01-10T16:42:02+00:00Athkur Sumaneditor@ijpba.inAnkur Onieditor@ijpba.in<p style="font-weight: 400;">The research also looks at whether or not these views differ based on other demographic categories. The pervasiveness of e-marketing has an effect on customers' online shopping habits, including when, where, and what they buy. It also impacts consumers' preferences, decisions, and newline way of life. People's lifestyles now include online buying. It's hard to deduce the underlying motivations behind customers' choice to buy some products over others. The effect of e-marketing on online shopping habits must be investigated. The dominance of digital channels in marketing has led to a general trend away from more conventional strategies. On July 15, 2020, PRNewswire reported that the total value of digital advertising and marketing will rise to US$640.2 billion by 2027, representing a compound annual growth rate (CAGR) of 10.3 percent between 2020 and 2027. The market for displays is forecast to rise at a CAGR of 12%, reaching $350.6 billion, over the next five years.</p> <p><strong>KEYWORDS </strong>Customer Satisfaction, Traditional marketing, Consumer Behavior, Company</p>2024-01-05T00:00:00+00:00##submission.copyrightStatement##http://www.ijpba.in/index.php/ijpba/article/view/454FORMULATION AND EVALUATION OF NANOGEL CONTAINING ALOE BARBADENSIS2024-01-13T04:53:28+00:00Deepak Koshtieditor@ijpba.inRicha Mishraeditor@ijpba.in<p style="font-weight: 400;">Nanogels are promising and innovative drug delivery system that can play a vital role by addressing the problems associated with old and modern therapeutics such as nonspecific effects and poor stability. Nanogels appear to be excellent candidates for brain delivery. One future goal of research in this area should be the improved design of microgels/nanogels with specific targeting residues to enable highly selective uptake into particular cells. In this study an attempt was made to prepare and evaluate Nanogel of containing <em>Aloe barbadensis.</em></p> <p><strong>Keywords: </strong>Nanogel, <em>Allium cepa</em><strong><em>, </em></strong>drug release, particle size, drug entrapment efficiency</p>2024-01-05T00:00:00+00:00##submission.copyrightStatement##http://www.ijpba.in/index.php/ijpba/article/view/455The Study of Challenges and Possibilities Pertaining to HR in Indian Retail Companies2024-01-22T15:13:50+00:00Lehri Singh Chauhaneditor@ijpba.inAmit Sainieditor@ijpba.in<p style="font-weight: 400;">It aims to offer a perspective on human resource management (HRM) in contemporary Indian retail enterprises and was one of the pioneers in this sparsely explored field. The primary goal of the study was to investigate the issues and opportunities related to human resources that contemporary Indian retail organizations face. The study focused on multi-brand retail companies in Delhi and the National Capital Region. To meet the study's predetermined goals, a total of two questionnaires were created.</p> <p><strong>KEYWORDS: -</strong> goals, HR Opportunities, Challenges, departments, retail, companies</p>2023-12-29T00:00:00+00:00##submission.copyrightStatement##http://www.ijpba.in/index.php/ijpba/article/view/448Multi-Level Evidence-Based Practice Training Program (MITP-EBP) on Health Outcomes for Patients2024-01-29T03:44:02+00:00Korada Raga SravanthiEDITOR@IJPBA.INSneha Sahay YouthamEDITOR@IJPBA.IN<p style="font-weight: 400;">Allied Health and Nursing Resources Section of the Medical Library Association is funding this research as part of its Phase I initiative to create a nursing literature map.<strong> T</strong>he main aim of the study is to Multi-Level Evidence-Based Practice Training Program (MITP-EBP) on Health Outcomes for Patients<strong>. </strong>Polit and Hungler state that a research study's a representative cross-section of a larger population. In research, a sample is the fundamental unit from which data must be culled, or the people who take part in the study. Here, we set out to measure the effects of MITP-EBP on nursing education and patient care outcomes in two contexts (academic and clinical) using data collected from three groups of nurses: nurse educators, postgraduate nursing students, and clinical nurses.</p> <p><strong>Keywords: </strong>Multi-Level, Evidence-Based, Practice Training Program, Health, Patients, etc.</p>2024-01-29T03:44:02+00:00##submission.copyrightStatement##http://www.ijpba.in/index.php/ijpba/article/view/447Evaluating and Comparing the Experimental and Control Medical Students' Knowledge and Functional Health Issues Groups Before and after Testing2024-01-29T03:44:26+00:00Cherukuri SowmyasriEDITOR@IJPBA.INSneha Sahay YouthamEDITOR@IJPBA.IN<p style="font-weight: 400;">Researchers used family-centered nursing treatments in the third stage. These that were teaching families about solving functional health issues with the use of flashcards, suggesting changes that could be made to the home environment to help prevent falls, and teaching families about good night's sleep and deep breathing to help them wind down better. Information was reinforced and exercise was adhered to through direct visits using notes and a video show. After one, three, and six months, participants were given a post-test. This is what After six months (Post test 3), information on the data analysis's outcomes was made public instability, disturbed sleep, and understanding among the elderly and those who care for them after Family Focused Nursing Interventions (FFNI) were given.</p> <p><strong>Keywords:</strong> nursing, treatments, Interventions. Functional Health, teaching</p>2024-01-29T03:44:26+00:00##submission.copyrightStatement##http://www.ijpba.in/index.php/ijpba/article/view/446Community-Based Case-Control Study to Evaluate the Mental Health Disorders for Suicide2024-01-29T03:44:51+00:00Haritha Kotaeditor@ijpba.inPeter Jasper Youthameditor@ijpba.in<p style="font-weight: 400;">In order to improve students' understanding and perspective on suicide, the intervention research used a systematic educational intervention. Many members of the local community saw suicide as a way out of interpersonal, familial, and financial problems, according to the qualitative research. This was true for both healthy persons and those suffering from mental illness. Only a small the psychological autopsy revealed the proportion of suicide victims who suffered from severe mental illness investigation. Psychosocial stress and social isolation also showed up as potential causes of suicide among local residents, according to the psychological autopsy research.</p> <p><strong>Keywords: </strong>students', intervention, suicide, Mental Health Disorders, Community-Based Case-Control</p>2024-01-29T03:44:51+00:00##submission.copyrightStatement##http://www.ijpba.in/index.php/ijpba/article/view/458The Standardization and Quality Control of Herbal Remedies2024-01-29T13:12:46+00:00Ritwik MishraEDITOR@JDDT.INVivek GuptaEDITOR@IJPBA.IN<p style="font-weight: 400;">The use of herbal remedies in modern medicine is becoming more well-known and widely accepted. It is well-known that more than 80% of the global population relies on herbal remedies and products for a healthy lifestyle, even if the majority of these uses are unconventional. Additionally, the methods for ensuring the high quality and standardization of herbal remedies were covered.</p> <p><strong>Keywords:-</strong> Herbal medicine, standardization, quality control.</p>2024-01-05T00:00:00+00:00##submission.copyrightStatement##http://www.ijpba.in/index.php/ijpba/article/view/463A Review on Herbal Plants with Hepatoprotective Effects2024-02-20T06:22:09+00:00Sumit Jaineditor@ijpba.inSomkant V Jawarkareditor@ijpba.in<p style="font-weight: 400;">The development of liver illnesses has emerged as a serious concern in world health. These diseases may be caused by several harmful compounds, such as chemotherapeutic drugs, thioacetamide, carbon tetrachloride, certain antibiotics, heavy alcohol use, and harmful bacteria. Therefore, excellent health and well-being depend on maintaining a functioning liver. Synthetic drug drawbacks have surpassed their benefits, despite pharmacological advancements. Contemporary medical approaches to liver disease treatment are not only inefficient, but also linked to harmful side effects and very high prices, making them unaffordable for underdeveloped nations. Therefore, there seems to have been a global upsurge in interest in investigating medicinal plants as potential alternative treatment agents for illnesses. These plants are readily accessible, inexpensive, and do not need labor-intensive pharmaceutical manufacturing methods. The focus has so been on traditional herbs that are very effective, have minimal toxicity, and are cost-efficient. This research presents the results of a literature search that used many databases, including PubMed, ISI Web of Knowledge, and Google Scholar. We reviewed all available material on medicinal plants from throughout the globe that have the potential to protect the liver. Additionally, we covered phytochemical substances that have hepatoprotective properties, and we concluded by highlighting upcoming research in the topic.</p> <p><strong>Key words: </strong>Bioactive compounds, hepatotoxicity, liver diseases, medicinal plant, pharmacology.</p>2024-01-05T00:00:00+00:00##submission.copyrightStatement##http://www.ijpba.in/index.php/ijpba/article/view/464Optimizing Fluorouracil Delivery for Enhanced Efficacy in Colorectal Cancer Treatment2024-02-20T06:24:12+00:00Siddharth VermaEDITOR@IJPBA.INMayank MandhanyaEDITOR@IJPBA.IN<p style="font-weight: 400;">Fluorouracil (5-FU), a mainstay in colorectal cancer therapy, has demonstrated significant efficacy, yet challenges persist in maximizing its clinical impact. This article aims to explore recent advancements in optimizing fluorouracil delivery systems to enhance its therapeutic effectiveness. We delve into the molecular mechanisms underpinning fluorouracil's antitumor activity, examine its current clinical applications, and critically evaluate emerging strategies for targeted drug delivery. The article synthesizes findings from recent studies on nanoparticle formulations, personalized medicine approaches, and combination therapies, providing a comprehensive overview of the evolving landscape in fluorouracil research. The synthesis of these insights contributes to our understanding of how tailored drug delivery systems can potentially revolutionize the treatment paradigm for colorectal cancer.</p> <p><strong>Keywords : </strong>Fluorouracil , colorectal cancer , maliganancies , suboptimal drug delivery.</p>2024-01-30T00:00:00+00:00##submission.copyrightStatement##http://www.ijpba.in/index.php/ijpba/article/view/465A Review on Antioxidant Potential of Medicinal Plants2024-02-24T13:24:46+00:00Chetna R. Kotharieditor@ijpba.inShirish P. Jaineditor@ijpba.in<p style="font-weight: 400;">Many research studies have proposed that about two-thirds of the medicinal plant species of the world possess significant antioxidant potential. Antioxidants are very beneficial as they decrease oxidative stress (OS) in cells and hence play theirrole in management as well as treatment of numerous diseases like cancers, cardiovascular diseases, as well as manyinflammatory illnesses. This review comprises the antioxi- dant potential of numerous parts of medicinal plants like leaves,stems, roots, seeds, fruits, as well as bark. Synthetic antioxidants named butylated hydroxyanisole (BHA) as well as butylated hydroxytoluene (BHT) are extensively employed in foods because of their role as food preservatives. Severalnatural antioxidants have better efficacy as compared to synthetic antioxidants. These medicinal plants include <em>Gera- nium sanguineum </em>L., <em>Rheum ribes </em>L., <em>Diospyros abyssinica</em>, <em>Sargentodoxa cuneata </em>Rehd. Et Wils, <em>Pistacia lentiscus</em>, <em>Ficus microcarpa </em>L. fil., <em>Polyalthia cerasoides </em>(Roxb.) Bedd, Cunn, <em>Teucrium polium </em>L., <em>Crataeva nurvala </em>Buch-Ham., <em>Urticadioica </em>L., <em>Dracocepha- </em><em>lum moldavica </em>L., <em>Momordica Charantia </em>L., <em>Acacia auriculiformis </em>A., <em>Bidens pilosa </em>Linn. The <em>Lamiaceae </em>species, Radiata, <em>Leea indica</em>, <em>Pelargonium endlicherianum, Salvia offici- </em><em>nalis </em>L., and <em>Uncaria tomentosa</em>(Willd.) DC. The literature study disclosed more side effects of synthetic antioxidants (including food additives) incomparison with natural antioxidants and for prevention of many diseases.</p> <p><strong>Ke</strong><strong>ywor</strong><strong>ds: </strong>Antioxidants, medicinal plants, oxidative stress, reactive oxygen species, sources of antioxidants</p>2024-01-30T00:00:00+00:00##submission.copyrightStatement##