Siddharth Verma
Research Scholar, Sunrise University, Alwar
Mayank Mandhanya
Research Supervisor, Sunrise University, Alwar
Abstract
Fluorouracil (5-FU), a mainstay in colorectal cancer therapy, has demonstrated significant efficacy, yet challenges persist in maximizing its clinical impact. This article aims to explore recent advancements in optimizing fluorouracil delivery systems to enhance its therapeutic effectiveness. We delve into the molecular mechanisms underpinning fluorouracil's antitumor activity, examine its current clinical applications, and critically evaluate emerging strategies for targeted drug delivery. The article synthesizes findings from recent studies on nanoparticle formulations, personalized medicine approaches, and combination therapies, providing a comprehensive overview of the evolving landscape in fluorouracil research. The synthesis of these insights contributes to our understanding of how tailored drug delivery systems can potentially revolutionize the treatment paradigm for colorectal cancer.
Keywords : Fluorouracil , colorectal cancer , maliganancies , suboptimal drug delivery.