Md Abdul Qayyum F Jahagirdar
Dept. of Pharmacy, Shri Jagdishprasad Jhabarmal Tibrewala University, Jhunjhunu, Rajasthan, India.
Rakesh Kumar Jat
Dept. of Pharmacy, Shri Jagdishprasad Jhabarmal Tibrewala University, Jhunjhunu, Rajasthan, India.
Abstract
Pithecellobium dulce leaf (Fabaceae) is a medicinal plant used in the treatment of many clinical conditions in India. Its adaptogenic potential activity has been investigated in this study using albino mice and rats. The methanolic extract of Pithecellobium dulce leaves was prepared and subjected to preliminary qualitative phytochemical screening. Flavanoids, Tannins and Alkaloids were found to be present. Acute toxicity studies were carried out in albino mice. The methanolic extract did not show the lethal effect at a dose of 2000mg/kg body weight with no signs of abnormalities or any mortality observed for 14 days period. Anoxia stress tolerance test, Swimming endurance test, Immobilisation stress models were used to investigate the adaptogenic potential of title plant. The results indicate that pretreatment with methanolic extract of leaves of Pithecellobium dulce exhibited significant adaptogenic potential activity at the tested doses of 125mg/ kg and 250 mg/ kg 500 mg/kg. On the basis of results, it was concluded that Pithecellobium dulce leaves possess adaptogenic potential activity.
Keywords: Pithecellobium dulce leaf, anoxia stress tolerance test, swimming endurance test model, Immobilization stress.