Aniruddh Verma
Research Scholar, Faculty of Pharmacy, Oriental University, Indore-453555, Madhya Pradesh, India
Kratika Daniel
Faculty of Pharmacy, Oriental University, Indore-453555, Madhya Pradesh, India.
Sachin K Jain
Faculty of Pharmacy, Oriental University, Indore-453555, Madhya Pradesh, India
Abstract
In the current study, liposomal formulations of the antiretroviral drug tenofovir disoproxil fumarate (TDF) will be developed and evaluated for controlled distribution. By utilizing different non-ionic surfactants (span-20, span-60, and span-80) and cholesterol in different ratios to obtain improved drug permeability at the targeted site of action, which considerably lowers dosage frequency and hence improves patient compliance, niosomes were formed by ether injection. The efficacy of entrapment, vesicle size, zeta potential, and surface shape of the generated vesicles were evaluated by TEM and in-vitro release. According to the TEM findings, the niosomes produced were white, round, and had a defined interior aqueous area with uniform particle size. The composition F5, which contained cholesterol and span 60, was the most beneficial (2:1).