Protective Effect of Methanolic Extract of Sida Veronicaefolia against Paracetamol Induce Hepatotoxicity in Experimental Animals

Abstract

The present study was intended to evaluate the hepatoprotective activity of Methanolic Extract of the leaves of Sida veronicaefolia (MESV). The Methanolic Extract of the leaves of Sida veronicaefolia (MESV) at dose 250 & 500 mg/kg were administered orally to the animals with hepatotoxicity induced by paracetamol. Silymarin (25mg/kg) was given as reference standard. The hepatoprotective activity was also supported by histopathological studies of liver tissue. An effective significant alteration in all biochemical parameters and histopathological sections was observed. Since results of biochemical studies of blood samples of paracetamol treated rats showed significant increase in the levels of serum enzyme activities, reflecting the liver injury caused by paracetamol and blood samples from the animals treated with the oral administration of Methanolic Extract of the leaves of Sida veronicaefolia (MESV), produced a significant reduction in serum enzymes alanine aminotransferase (ALT), aspartate aminotransferase, (AST), alkaline phosphatase (ALP) to the acute hepatotoxic induced rats. They exhibited a significant inhibition of hepatic toxicity by using various marker enzymes and the histopathological analysis. From these results, concluded that the Methanolic Extract of the leaves of Sida veronicaefolia (MESV) was effective in protecting the liver against the injury induced by paracetamol in rats at the dose of 250 & 500 mg/kg/body weight. These results suggest that leaves of methanolic extract of Sida veronicaefolia (MESV) may supports the hepatic cells protection.