Nirmesh Sudhikumar Kothari
Assistant Professor Dept. Of Medicine Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences Sawangi (Meghe) Wardha
Pallav Thakre
Assistant Professor Dept. Of Medicine Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences Sawangi (Meghe) Wardha
Abstract
Introduction: Homocysteine (HCY) is a methionine metabolism intermediate product. Disturbances in liver function are likely to impair methionine and HCY metabolism, resulting in elevated blood HCY levels. In addition to its established function in cardiovascular disorders, hyperhomocysteinemia may be a risk factor for cirrhotic individuals. HCY levels are higher in those who have low folate levels and a mutant methylene tetrahydro folate reductase. Hyperhomocysteinemia is caused by a reduction in Vitamin B12 and folic acid levels in the cells, which raises HCY levels in the blood.
Aim: Effect of Non-Alcoholic Liver Disease in Homocysteine Level
Material and Method: This study included total 40 patients 20 NAFLD Patients and 20 normal subjects were comes from OPD and IPD. Patients went to the Directly Observed Treatment Short-course focus in the Dept. of General Medicine
Result: To the comparison between both groups Homocysteine level are elevated in patient group as a compare to control group. The value is statistically significant (p < 0.01).
Conclusion: Because they act as coenzymes in methionine-HCY conversion, HCY is linked to Vitamin B12 and folic acid. When this vitamin is deficient, HCY builds up in the body and circulates more freely. As a result, hyperhomocysteinemia is a major risk factor for CLD, particularly alcoholic liver disease, in addition to being a risk factor for coronary artery disease.
Keywords: Homocysteine, Liver disease, methionine, Vit-B12, CLD.