D.B. Joshi
Department of Pharmaceutical Chemistry, Shrinathji institute of pharmacy, Nathdwara, Rajasthan
R.S. Bhadauria
Shrinathji institute of pharmacy, Nathdwara, Rajasthan
Abstract
Atenolol is a commonly used beta-blocker that is advocated for the treatment of hypertension. The Objective of the present work was to formulate and evaluate mouth dissolving tablets of Atenolol by selecting suitable taste masking agent and super disintegrants for better patient compliance. The availability of various technologies and the manifold advantages of ODT will surely enhance the patient compliance, low dosing, and rapid onset of action, fast disintegration, low side effect, good stability and its popularity in the near future. In the present work, oral dispersible tablets of Atenolol were prepared by direct compression method using three superdisintegrant namely Cross povidone, Croscaramellose sodium, sodium starch glycolate. All the tablets are subjected to drug content uniformity, hardness, friability, wetting time, water absorption ratio, disintegration, dissolution, drug excipients interaction and short-term stability studies.
Keywords: atenolol, CPS,SSG, povidone.