EFFICACY OF PLANTAGO OVATA MUCILAGE USED ON RAPIMELTS TABLET OF METACLOPRAMIDE HCL

Abstract

To achieve taste masking of drug. prepare preliminary trial batches of rapimelts using plantago ovata mucilage as natural superdisintegrant and crosspovidone as synthetic superdisintegrant by direct compression method. Rapimelts tablet of metoclopramide Hcl tablets by determination of range of technological parameters. Dissolution profile suggested that tablet prepared with Plantago ovate mucilage were capable of releasing up to 90 % drug within 15  minutes in phosphate buffer 6.8 pH, by an appropriate combination of excipients it is thus possible to obtain Rapimelts tablet of metoclopramide Hcl tablets using simple and conventional technique.different ratio of drug and polymer. To Evaluate the drug polymer complex and finally which polymer and ratio of drug and polymer is better to formulate final formulation. To achieve taste masking of drug. To prepare preliminary trial batches of rapimelts using plantago ovata mucilage as natural superdisintegrant and crosspovidone as synthetic superdisintegrant by direct compression method. To evaluate the prepared rapimelts for various properties like friability, hardness, wetting time, water absorption ratio, disintegration time, drug content, drug  etc. Identifying the key variables and their levels for applying factorial design and to optimize one formulation. To evaluate the final batches and find out the optimized batch based on statistical optimization using experimental design. To compare the optimized formulation with marketed preparation. To carry out stability studies of optimized batch as per ICH guidelines. The aim of the present investigation was to Formulate, designed, and evaluate plant agoovata mucilage used as a natural superdisintegrant was to developed and optimized rapimelts containing Metoclopramide HCL.